Damian Wolfe's Blog

Smith and his colleagues accordingly inoculated some rabbits with the recombinant…

damianwolfe — Sun, 04 Jul 2010 08:36:31 +0000

Smith and his colleagues accordingly inoculated some rabbits with the recombinant and measured the amount of antibody the animals produced.
This proved to be far in excess of the minimum required for immunity, and although the researchers cannot be certain of directly comparable results in man and the prospects seem reasonably good.
The hope cherished by the NIH team is that recombinant vaccinia viruses may be used to combat hepatitis B virus in Africa and Asia according to exactly the same strategy that succeeded so brilliantly with smallpox. But there are two snags.
First, vaccinia itself is not without its dangers: vaccination against smallpox carries a risk of encephalitis serious enough to have prohibited its use in countries where smallpox was not endemic well before the success of the eradication campaign.
That means the recombinant virus would never be used in Europe and North America.
In Asia and Africa however, Smith argues and the benefits would far outweigh the risks ” as they did with smallpox.
The other snag, ironically, arises from the very success of the smallpox vaccination campaign ” because, as a result, most of the population of the Third World is already immune to vaccinia and wouldn’t allow it to flourish long enough to produce the hepatitis antigen. TECHNOLOGY
Happy days for software pirates
OVER the past two months, an electronic device called the 810 enhancement has been arriving in Britain from the US.
The American company that makes the 810, Happy Computing of California, calls it the “Happy Chip”.
But the name raises no smiles among computer manufacturers and software houses: Happy Chip is a tool for copying programs for Atari home computers.
Although it has innocent uses, devices like Happy Chip enable pirates to steal programs worth millions of pounds. Software companies are reluctant to say how much piracy costs them.
Psion Software, which produces material for Sinclair home computers, puts the figure at £29 million a year ” 30 per cent of its turnover. The pirates are even less keen to say how much they make.
The authorities have uncovered large-scale illicit operations in the US (a software company called Micro-Pro International won $250000 damages from one pirate) but no one has yet been prosecuted in Britain.
This is partly because piracy in Britain is more a game for enthusiasts than a serious business.
Operations centre around computer clubs and groups of enthusiasts who cannot resist the challenge of copying something designed to be uncopiable (see Box).
The pirates play an intricate and expensive cat-and-mouse game with computer firms.
As the pirates crack the latest “protection programming”, or copyguarding and the software writers devise new methods that are harder to crack. In Britain and the hobby is growing.
Most groups of pirate enthusiasts number around 10, but New Scientist has heard of a group of 60 people swopping bootleg software.

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Daggers go in…

damianwolfe — Sat, 03 Jul 2010 04:00:04 +0000

Daggers go in
Mobile Adventure have relinquished their dealership on Old Town canoes and will, instead, concentrate on their Dagger franchise.
In future, Old Town will be represented by buoyancy aid manufacturers Plastimo who are owned by Old Town’s parent company. Palm have taken on the franchise for Dagger kayaks.
Ace and Perception see these as compromising the position of Palm relating to sales of their own kayaks with the result that Perception have withdrawn wholesale facilities from Palm and the special relationship between Ace and Palm has effectively ended.
A battery of three ovens (plus the ex-Scanro one waiting in the corner for assembly) and an impressive array of moulds make AC Canoe Products very strongly placed to forge ahead with the production of rotationally moulded kayaks.
Their own range plus the Scanro range have been relaunched with new graphics and the Breaker wave skis have been acquired and there are also the Scanro pontoons, Vinta sailboards and a sailing dinghy and the Dolfin, for Robin Witter to play with if he gets bored!
Ace have also joined those able to manufacture in 3 ply polyethylene and the chemicals used being claimed to be safer for workers than those used by other companies although long term properties such as UV stability have still to be checked.
Palm and AC Canoe Products are acting as importers for the Kober range of paddles with their Shock Absorbing System, a foam system which lets dropped paddles bounce higher without breaking. The Magnum retails at £79.95 and the Magnum Extreme at £89.95.
Helios are manufacturing 70, 105 and 325l Stuff Sacks, priced from £16.39 to £23.44, featuring roll over and clip seals. They also have a 220mm x 150mm x 90mm drybox for first aid kit or documents.
Eurocraft are making the Rapid Discovery, a hybrid craft intended to bridge the gap between canoes and rafts.
Narrow in shape, it can be used as a support and rescue craft and for disabled paddlers as well as in its own right. It packs into a 115l backpack for carriage over short distances. Sea kayaks are colourful this year.
P&H Orion, Icefloe and Iona and North Shore Freewater.
Pyranha towline system on a Magic Bat.
The two packets are floats for the karabiners.

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There a chemist who had recently worked for a company involved…

damianwolfe — Tue, 29 Jun 2010 23:05:02 +0000

There a chemist who had recently worked for a company involved in the manufacture of submarine telephone cables recognised its similarity to gutta percha ” the material used to sheathe such cables. Tests showed that polythene was superior to the natural material.
Within a short time, his former employers ordered 100 tons of the new material and thus making it worthwhile for ICI to build a production plant.
The world’s first polythene plant came on stream the day that Hitler invaded Poland.
Subsequently, polythene played an important part in radar during the Second World War.
Afterwards, when ethylene became available on a large scale from oil refining processes ” previously it had been made from alcohol ” the price of the polymer dropped.
It then entered the domestic market to begin the explosive growth towards today’s production level of millions of tonnes a year. Australia’s new technological guru
Jane Ford cables an interview with a new science and technology minister
LATERAL THINKER and rapid-fire ideas man, ex quiz king and schoolteacher and lawyer ” Australia’s new Science and Technology Minister, Barry Jones, is something of a phenomenon in Australian politics.
Unlike most politicians he is passionately interested in technology and its social implications. Jones’s recent book “Sleepers Wake !
Technology and the Future of Work “crystallises many of his most radical ideas and has become compulsory reading, particularly in the corridors of his new department. The book has already sold out a sixth edition.
In it Jones challenges the concept of full employment and questions the relevance of the work ethic and advocates the redefinition of work to include domestic labour and hobby activities.
He emphasises the need for recurrent education and presses for guaranteed incomes for all and a national superannuation fund.
The new minister admits that all this could take eight to ten years and an improved economic climate but he is adamant that attitudes must change.
Australia, he adds, has entered a post-industrial period and without radical alternatives and a revolution of the traditional industrial base its society will crumble.
Almost single handedly in the past three years Jones has made high technology and the “sunrise” industries household words and created a climate of industrial and community awareness.
He describes Australia’s traditional industrial base as geriatric and virtually past salvation.
The country’s only hope for economic recovery, he claims, is for it to turn to the highly skilled, “sunrise industries” that will generate wealth and cope with an expanding welfare bill.
Support for 16 of these sunrise areas, including biotechnology, custom made chips, computer software and scientific instrumentation and solar technology, is the cornerstone of his science and technology policy.
He plans to introduce new grants, government loans and schemes to stimulate the new technical industries.
Whether this will be sufficient to catalyse the country’s moribund industry and boost its declining research effort is debatable.
But Jones is the perpetual optimist ” even in the face of a declining economy and a budget deficiency of $A96 billion.
“The size of the deficit simply indicates the need to change the whole economic base of the country,” he says.

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That great orchestral war-horse, Mussorgsky’s Night on a Bare Mountain…

damianwolfe — Mon, 21 Jun 2010 18:52:59 +0000

That great orchestral war-horse, Mussorgsky’s Night on a Bare Mountain , comes off equally well and the orchestra playing with a winning combination of sheer gusto and precision.
We are and though, left with the question of exactly which orchestra we have had the pleasure of listening to: while the back cover of the jewel case states that both works have been played by the Canadians under Barshai and the inner notes suggest (unbelievably) that one of them may have been performed by the Bournemouth Sinfonietta under Norman Del Mar!
Another Canadian orchestra ” the Toronto SO conducted by Andrew Davis ” pops up on the all- Beethoven programme , consisting of the “Emperor” Concerto and the Fantasia for Piano, Chorus and Orchestra , and the King Stephen Overture , and the King Stephen Overture .
Anton Kuerti provides a vibrant and characterful solo contribution in the Concerto (though the slow movement is distinctly short on poetry), and the orchestra rises to the occasion well.
The far less frequently heard (and recorded)Fantasia goes with a swing ” the members of the Toronto Mendelssohn Choir adding their contribution with not only enthusiasm but also some subtlety ” and the Overture rounds off a generally recommendable disc.
The “Aspects”"Baroque Sampler”(), with the Toronto SO again under Andrew Davis, is a collection of such favourites as Pachelbel’s Canon , Albinoni’s Adagio , and Jeremiah Clarke’s Trumpet Voluntary .
Purists may not be too keen on the “big band” approach, but these are nonetheless vital and energetic performances which convey much enthusiasm, and would probably serve as a more palatable introduction to seventeenth and eighteenth century music for the newcomer than some of the odder products of the “authentic”movement.
Oddly enough, great claims of “authenticity”(“First recordings of the original… Scores”) are made on a disc of the original music of George Gershwin ().
Alicia Zizzo is the soloist in the Rhapsody in Blue and the Piano Concerto in F , and also plays the original 1919 piano version of the Lullaby ; she is accompanied by the George Gershwin Festival Orchestra under Michael Charry, and they contribute the Cuban Overture of 1932 as well.
The latter is certainly played with great energy although even such a generally obvious piece such as this would have benefitted from heightened sensitivity: Gershwin was, after all, influenced not just by the vibrant colours of the tropics but by their warmth as well.
Zizzo plays the Concerto well enough, capturing the atmosphere of Broadway effectively, while still relating the work to its classical roots (natural son of Rachmaninov in places), and the orchestra, clearly happier in this idiom than int he Overture , provides fine support.
The Rhapsody in Blue brings the most effective performances on the disc, but even at this price level the competition is so intense (Gwenneth Pryor on Pickwick ; Jerome Lowenthal on Vanguard ; CfP’s Daniel Blumenthal) that only a general recommendation can be given.
The Scott Joplin revival of the ’60s and ’70s ” with the complete piano works on an RCA boxed set, and the naive but worthy opera Treemonisha on DG no less!” seems to have run its course.
But John Arpin’s well recorded selection of fourteen piano rags, waltzes and dances () can still be welcomed.
The opening Maple Leaf Rag is an unfortunately hard-driven introduction to the set, but matters improve thereafter with more subtlety and refinement in the less fraught pieces.
For really top class Joplin you need pay only a little more for a selection from Dick Hyman’s complete survey mentioned above, but at less than a fiver, Arpin’s disc will do very nicely for a representative sample of Joplin ” which is really all I can take in a single sitting!
The remaining two discs in my “Aspects” batch are both based on the musical theatre:”Broadway Favourites!(), features the Winnipeg SO under Erich Kunzel in a very well played selection of numbers from My Fair Lady, Lady Be Good, Annie Get Your Gun, The Fantasticks, Man of La Mancha, Guys and Dolls, Cats and a suite of waltzes based on the music of Richard Rodgers.
All very “Friday Night is Music Night” and, as listening figures show and there’s clearly nothing wrong with that! The talented baritone is left scandalously anonymous.
The artists on the disc entitled “Films and Shows”(), are, on the other hand, far from anonymous and include Sarah Brightman no less. There are selections from Oliver!,
Snoopy, The Wizard of Oz,, and The Nightingale ” all sung, in general, with commitment and enthusiasm.
The boys of King’s College School (not King’s college, as listed on the cover) perform with appropriate gusto in the Lionel Bart numbers, and there are strong contributions from the adult professionals and the National So under John Owen Edwards.
The songs from Snoopy and The Nightingale are not so immediately appealing to anyone who doesn’t know the shows, but the casts are strong and put the numbers across with confidence and verve.
The music of The Wizard of Oz is, of course, more familiar to most people, and it’s performed well here: Gillian Beven’s Dorothy, very much in the Judy Garland mould, is featured in every strong, providing sound foundation for each, and my only real grouch was that the children’s chorus was far less easy on the ear than that used in Oliver .
If “Aspects” is a bargain priced label and then the other new exclusive Woolworths series “The Classics”is in the middle range (currently £7.99 per disc).
Our first taste features the clarinetist James Campbell and the National Arts Centre Orchestra of Canada conducted by Franz-Paul Decker:Mozart’s Clarinet Concerto K622 is coupled with the big one by Copland, and the Weber’s Concertino for clarinet and orchestra.
The opening of the Mozart reveals an excellent orchestral ensemble, and the soloist’s contribution is individual and well-characterised, making this a very desirable version indeed.
Copland’s lovely, lyrical work, with a strong element of jazz in the final section and receives another excellent performance ” although it fails to dislodge the uniquely authoritative account recorded by Benny Goodman (who commissioned the work) and the composer ” and Decker is equally masterly and convincing in the very different requirements of Weber’s lighthearted Concertino .

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What inspired such reckless aspirations?

damianwolfe — Mon, 14 Jun 2010 19:58:46 +0000

What inspired such reckless aspirations?
What boosted Peron’s ego?
A partial answer might be that he was confident at the time that Argentina would be the first country to exploit atomic energy for industrial purposes.
For on Saturday, 24 March, 1951, on the eve of a conference of foreign ministers of pan-American states and the president announced to the press, “Argentina produces atomic energy” President Peron introduced Professor Ronald Richter to the press as the scientist responsible for the project, and later decorated him with the Peronista Medal.
The gist of Peron’s statement and shorn of its chauvinism and sanctimony, was that at an atomic energy plant on Huemul Island near San Carlos de Bariloche, Argentinian scientists had recently achieved the controlled liberation of atomic energy from thermonuclear reactions.
They had done this using processes analogous to those which provided the energy of the Sun.
The thermotron, as the apparatus was called, did not rely on the principle of the hydrogen bomb. Instead it utilised materials less costly and more readily obtainable.
Even in today’s nuclear age such a claim would be widely reported; three decades ago it was front-page news throughout the Western world. The British press did its homework.
Huemul turned out to be a small island in lake Nahuel Huapi, high on the slopes of the Patagonian Andes.
The surrounding district was a national park and the summer and winter playground of rich South Americans.
Ronald Richter, aged 42, was a little-known Austrian-born physicist, one of many German-speaking scientists and technicians who turned up in Argentina in the late 1940s.
Scientific correspondents of the UK press expressed surprise rather than incredulity at the Argentine claims.
This was because the scientific elite of the Athenaeum, on whom the correspondents relied, were well aware that research on controlled thermonuclear reactions was already being furtively pursued in a few British laboratories.
The scientists were hesitant to accept the claims of such a nonentity as Richter without corroboration. Reaction in the US was very different.
The press blustered; the claim was “impossible under the immutable laws of nature” and said the New York Times .
(such an outward display of scepticism towards foreign achievement was later to greet the news of Sputnik 1.) But behind the scenes the claims were taken more seriously.
The government of the US wasted little time in funding two secret thermonuclear research projects.
Labelled as Sherwood and Matterhorn and the projects were headed by Jim Tuck and Lyrnan Spitzer respectively.
In view of the distrust of British security then prevailing in the US in the aftermath of the Fuchs case and the transparency of these code-names is noteworthy.

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So in these three cities, a total of 78 males…

damianwolfe — Tue, 01 Jun 2010 04:24:28 +0000

So in these three cities, a total of 78 males and 78 females had intermarried. While only 25 males and 7 females were married to hearing persons.
In addition and there were over ten deaf children resulting from deaf intermarriages, and only two or three from a marriage of a deaf person to a hearing person ” this being a deaf mother married to a hearing man, and the deaf mother’s father was also deaf.
The statistics given of one in seven offspring of deaf parents being deaf themselves, as opposed to one in 135 offspring of deaf-hearing parents being influenced Dr. Buxton to argue against the desire of deaf people to intermarry.
These statistics were probably available to Dr. Alexander Graham Bell when he raised the spectre of a “deaf variety of the human race”. The Growth of Deaf Missions and Associations.
The founding, and the success, of the first five adult organisations for the deaf in Britain at Glasgow, Edinburgh, London (St. Saviours), Manchester and Leeds prompted many deaf people in other parts of the country to seek the same sort of opportunities for themselves.
In the case of the first one to be founded after 1850 ” Dundee in 1853 ” a deaf person, Alexander Drysdale who was then headmaster of the Dundee School for the Deaf took the lead to establish an adult mission.
This was quickly followed by deaf people in Liverpool (George Healey ” 1864), Birmingham (W.A. Griffiths ” 1867), Stoke-on-Trent a. Davis ” 1868), Cardiff a.
Rowlands ” 1869), Kilmarnock (James Paul ” 1874) and Aberdeen (1879).
Many of these deaf men served the needs of their fellow-men for years ” in George Healey’s case until his death in 1927!
Other missions and adult societies for the deaf were formed by local interested persons, mainly clergymen.
Often and this interest was aroused by the tireless efforts of the Rev. Samuel Smith of St. Saviour’s Church, London, in visiting numerous locations. This was the case in places such as Leicester, Nottingham, and Southampton.
In London it was found that deaf people in East and South London had difficulty in getting to St. Saviour’s Church and so in the same year, 1873 and two new branches were opened ” one at St. Barnabas Church, Deptford (forerunner of Lewisham Deaf Club) and at West Ham. Some societies and such as the Bolton and District Society, and
others at Halifax (1860), Sheffield (1861), and Bradford (1864) were offshoots of the original societies at Manchester and Leeds.
The same was true of Greenock (1870) and Paisley (1874) in Scotland (from Glasgow).
In Northern Ireland and the Kinghan Mission was founded in 1857 in Belfast due to the interests of the Rev. Kinghan who was then Headmaster of the Ulster Institution. The National Deaf and Dumb Society
The rapid growth of adult missions and societies prompted a few determined men led by James Paul to found the National Deaf and Dumb Society in 1879, with James Paul as the first secretary.
Unfortunately and this was short-lived and it folded in 1884 having been torn asunder by internal dissensions, but before its collapse it inaugurated two important undertakings and the Stockton-on-Tees Mission and the Ayrshire Mission to the Deaf and Dumb.
The formation of the National Deaf and Dumb Society, however, laid the ground for the foundation of the British Deaf and Dumb Association eleven years later. Deaf Sports Clubs

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She finished 22nd in the women’s race and was fifth…

damianwolfe — Mon, 24 May 2010 17:33:54 +0000

She finished 22nd in the women’s race and was fifth in the veteran over-35s. Husband Godfrey Rhimes is finding some form at last.
He returned 1 hr. 19 mins. 44 secs., his best for some time, he finished in 162nd position.
Due to injuries and unavailability and the team for the national cross-country championships at Newark (Notts) was severely reduced.
The race was run on a fast and flat course around an old airfield, now used as a showground.
Eamonn Martin of Basildon AC ran away from the large entry of 2,200 runners to win in a time of 40 mins. 29 secs.
For Alton, Mike Lake found some improved form after a long time out with injury and to come 899th in 50 mins, 05 secs. Keith Vallis was 1,134th in 5125, Graham Trott 1,262nd (5222).
Roger Sayer 1,793th (5544), John Harvey, 1,842nd (5643) and Doug McLean 2,061st (6002). The team’s overall position dropped to 208th this year.
The awards for last year’s performances were handed out at the club’s dinner/dance.
Jogger of the year was Sarah Rhimes and she also collected the ladies’ road race championship trophy for 1991.
The men’s senior road race champion for 1991 was the ever improving Matt Stevens. The veterans champion was also a new name on the trophy, Tony Wardley.
The improved runners’ trophies for the year were Graham Trott for the men, and Stephanie Hickman for the ladies. Pre-season meeting
The pre-season meeting for I’Anson/Miller Cup captains, vice-captains and umpires takes place at Wrecclesham pavilion on Thursday, April 23rd (not 22nd as originally arranged). Start 8 p.m.
Octopush girls delighted with 4th
Farnham Octopush Club ladies were delighted with their fourth placing in the national finals at Crystal Palace on Saturday.
Underwater hockey ” for that is what octopush is ” might be the ultimate non-spectator sport, but there was no doubting the commitment and team-work shown by the men’s and ladies teams in this championship.

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Unless your doctor were to go to the additional trouble of…

damianwolfe — Fri, 14 May 2010 06:08:42 +0000

Unless your doctor were to go to the additional trouble of writing on the prescription that he meant exactly what he had written, and was forbidding the chemist to substitute, you would get the cheapest product. It’s rather like the scene that I penned at the beginning of this column.
Now I must agree that the recommendation for generic substitution would provide savings for our poor beleaguered NHS. The DHSS estimates that it could save something around £30 million. The Guardian , in its wisdom, plucks out of the blue a figure of £200 million.
Any savings and though, would be at a huge cost to the British pharmaceutical industry and companies such as Beecham, Boots, Fisons, Glaxo, ICI and Wellcome.
The effect would be to damage those companies with a strong research base and some of their products would be replaced by imports from Eastern Europe, Italy and the Far East ” cheaper because they come from companies that do not support expensive R&D and a continuing technical back-up for their products.
Nowadays, from concept to production and the expenditure on research for a new drug can cost a cool £50 million. For 20 years the company owes the patent rights on its production.
Yet over the past two decades the period of development, of safety testing, and of approval, has risen from 3 or 4 years and to something like 10 years.
Thus nowadays a company may have less than a decade in which to recoup its investment.
If a scheme for generic substitution were to go ahead and the loss to British companies would not be limited to the so-called “savings” to the NHS, but the entire amount of the sales of such products. Why?
Most countries have some form of price regulation for pharmaceuticals, and, of course, prices are linked internationally.
A reduction of prices in Britain, as with OPEC, would have to be followed worldwide. The major British pharmaceutical companies are large exporters. Around 15 per cent goes to the home market and 85 per cent abroad.

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A little African ground squirrel gave a most…

damianwolfe — Thu, 13 May 2010 05:48:43 +0000

A little African ground squirrel gave a most convincing performance when examined by a zoologist. The young squirrel had been caught and placed in a box.
When the box arrived and the zoologist took the animal out to examine it, only to see it keel over and lie motionless on her hand.
No respiration was visible and the eyes were closed and the mouth gaped and the paws were rigid.
The zoologist was upset because she felt that the small animal had suffered from the journey in the box and she was responsible for its death.
She tried to feed it with a little warm milk, but there was no swallowing response.
Putting the “corpse” down and she gave up and was gazing sadly at the small body when, about two minutes after its “death”, it suddenly took a few very deep breaths and started to move about.
It became such a tame pet afterwards that she could never persuade it to play dead again, even if she grabbed it as though she were a predator. It was now too much at home with her for the response to be triggered. The animal most famous for shamming dead is, of course and the American opossum.
It is the species in which this curious behaviour has been studied most thoroughly, with some surprising results. When attacked and the opossum’s first reaction is to fight back.
It possesses a large number of small but very sharp teeth and can inflict a painful bite if given half a chance. It hisses like a snake, growls like a carnivore and snaps out at its tormenter. If this fails to deter the enemy and the possum promptly drops dead.
It collapses dramatically on to its side, its body limp and lifeless, its back slightly bent and its head turned down and so that it has a half-curled-up appearance.
Like the best fakers from the snake world, it displays a slackly open mouth with its tongue lolling out, and its eyes are half-closed. The American opossum has given its name to death-feigning.
When “playing possum” it lies limply on the ground and can even be bitten hard by an attacker without showing any response.
In this pathetic condition it is completely immune to any pain that may be inflicted upon it. Even if bitten or pecked it continues to lie limply on the ground. What is the mechanism in the animal’s nervous system that makes this possible?

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Carnon Consolidated has applied for planning permission to…

damianwolfe — Wed, 12 May 2010 16:41:41 +0000

Carnon Consolidated has applied for planning permission to extend underground by 2 kilometres toward another small settlement, Carharrack.
The company thinks that the ore in the new area runs to about 2 million tonnes, which doubles the mine’s existing reserves and would guarantee a total of 15 years’ production. Miners would start digging out the new supplies in 1985.
At present, Wheal Jane produces about 1600 tonnes of tin per year, about the same as South Crofty mine near Redruth.
Geevor and the third biggest mine, brings to the surface some 800 tonnes annually.
If the plan goes through and the mine would push further west from the workings acquired when Wheal Jane lined up with a second mine, Mount Wellington, a couple of years ago. Rio Tinto bought both mines in 1979 after its previous owners pulled out.
For Rio Tinto and the new scheme extends the interest it has shown in tin mining in Cornwall since acquiring Wheal Jane.
In that time and the giant multinational has bought a 40 per cent stake in the company that runs south Crofty (which also operates a small mine at Pendarves) as well as 18 per cent of the shares in Geevor.
Carnon Consolidated spends about £500000 a year on exploration, and says it is interested in opening up new and small mines in Cornwall, feeding the ore to the Wheal Jane processing plant. So far, however and the policy has still to come to anything.
It was interested in taking over a small mine called Wheal Concord but pulled out because financial prospects were poor.
Wheal Concord, at Blackwater, near Redruth, closed down in November and has yet to reopen. Cable debate Signals confusion
Barry Fox

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